Posts Tagged ‘Cancer’

How to Generate the Best Chemotherapy Drug

Thursday, March 11th, 2010

As a disease cancer consists of the uncontrolled malignant cellular growth, the invasion of organs and the metastasis. It seams that the cause of the condition is a combination of genetic predisposition and the exposure to some environmental toxins. Basically, the principle that makes a chemotherapy drug functional is the impairment of the cellular division of tissues with a fast growth rate. The fact that these drugs destroy cells leads to their being named cytotoxic.

In broad general terms, chemotherapy kills cells by means of chemical substances. In more particular terms, chemotherapy aims at destroying cancer and invasive micro-organisms that remain unaffected to other forms of treatment. Chemotherapy usually refers to antineoplastic drugs which are used to treat cancer or to the combination of these drugs into a cytotoxic standardized treatment regimen. From a non-oncological perspective, the term chemotherapy also refers to antibiotics – this is known as antibacterial chemotherapy.

A chemotherapy drug, or better a combination of such drugs, functions by destroying cells that divide quickly. Unfortunately, these drugs cannot make a selection between normal fast-dividing body cells and cancer cells. These other cells that get attacked by a chemotherapy drug are digestive tract linings, the bone marrow and the hair follicles. Thus, the main side effects of chemotherapy will include hair loss, the inflammation of the digestive tract and the reduced production of blood cells.

Among the other uses of the chemotherapy drug and cytostatic chemotherapy agents there are the treatment of autoimmune diseases (multiple sclerosis, rheumatoid arthritis) and the suppression of transplant rejections. More modern cancer treatments known as targeted therapy use anti-cancer medication that attacks only the abnormal proteins in cancer cells.

Different classes of chemotherapy drug medication are available at present. Thus there are antimetabolites, alkylating agents, topoisomerase inhibitors, anthracyclines and several others. Some newer agents, like monoclonal antibodies and tyrosine kinase inhibitors, do not interfere directly with the DNA as do the above mentioned ones.

These ones target a molecular abnormality in particular types of cancer such as chronic myelogenous leukemia or gastrointestinal stromal tumors. More special chemotherapy drug options only change the behavior of the tumor cells without affecting other tissues. Within these adjuvant therapies the option very commonly used is the hormone treatment. The decision to administer only one chemotherapy drug or a combination of several medicines belongs to the doctor and it is taken depending on the stage of the disease and the purpose of the treatment.

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Chemotherapy Drugs: All Information You Need to Know

Thursday, March 11th, 2010

Chemotherapy drugs are pretty numerous and they fall into various categories following such criteria as the way they work, the relationship they establish with other drugs and the chemical structure they have. The origin of most drugs is in herbal extracts that are afterwards processed and combined in laboratories. Don’t be surprised to find a drug classified in more categories, because there are many such cases in the medical world. Medical science and professional competence in the health care realm involves a good knowledge of chemotherapy drugs and their specificity.

A first category of chemotherapy drugs is the one relying on alkylating agents. These drugs have a very destructive effect on the bone marrow because they damage the DNA to stop the reproduction of the cancerous cells. This type of chemotherapy drugs is used in a wide variety of cancers and it is recommended only in small dosage to reduce the risk of leukemia that may appear 5 or 10 years after following the recommended chemotherapy treatment. The platinum based drugs are sometimes included in the same category because they act in a very similar manner against the disease.

Antimetabolites are another distinct class of chemotherapy drugs. They are prescribed for the treatment of ovary and intestinal cancers, breast tumors and leukemia and their impact is not limited to the DNA but also extends to the RNA too. The anthracyclines represent another variety of chemotherapy drugs being part of the antibiotic group. Their action is directed against enzymes that contribute to the DNA replication which is why they prove efficient in a large number of cancer cases.

Next is the category of inhibitors. The topoisomerase inhibitors separate and copy the DNA strands efficiently treating leukemia. The mitotic inhibitors are more natural-based derived from plants and they help in preventing enzymes from producing proteins required in cell reproduction. However, there is one huge risk that patients take when following such a treatment: these chemotherapy drugs may cause peripheral nerve damage to count only one of the health threats you may fear.

Last but not least, the corticosteroids represent chemotherapy drugs based on hormones and meant to treat myeloma, lymphoma and leukemia besides other diseases. In addition to reducing the cancer cellular growth, they also have a positive impact on the way the body reacts to chemotherapy by reducing the possibility of developing allergic reactions or digestive side effects such as vomiting and nausea. These types of drugs may be used as chemotherapy ones or not, depending on the purpose they are supposed to serve.

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